发明名称 |
Hydrophobic taxane derivates |
摘要 |
<p>This invention provides a taxane derivative of formula (I), wherein a hydrophobic organic moiety is attached to a taxane. R and R<1> is each independently H or a hydrophobic organic moiety, as long as at least one of R and R<1> is not H. Attachment of a hydrophobic organic moiety to the taxane so as to obtain a taxane derivative generally stabilizes the association of the derivative with a lipid, including a liposomal lipid, carrier in the plasma of animals to which the derivative-carrier association is administered. Also provided herein is a composition containing the taxane derivative and a pharmaceutically acceptable medium; desirably, the medium also contains a lipid carrier, and the derivative is associated with the carrier. Further provided herein is a method of administering taxane derivatives to animals, for example, animals afflicted with cancers. <IMAGE></p> |
申请公布号 |
EP1063234(B1) |
申请公布日期 |
2003.04.23 |
申请号 |
EP20000121129 |
申请日期 |
1996.01.11 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
MAYHEW, ERIC;FRANKLIN, J. CRAIG;BHATIA, SURESH;HARMON, PAUL A.;JANOFF, ANDREW S. |
分类号 |
A61K9/127;A61K31/335;A61K31/337;A61K31/66;A61P35/00;C07D305/14;C07F9/655;(IPC1-7):C07D305/14 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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