<p>The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.</p>
申请公布号
EP0871642(B1)
申请公布日期
2003.04.23
申请号
EP19960919290
申请日期
1996.06.07
申请人
CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人
MEADE, THOMAS, J.;KAYYEM, JON, F.;FRASER, SCOTT, E.