发明名称 |
A HYBRID FUSION PROTEIN TRANSCRIPTION REGULATOR TO INDUCE INTERFERON TARGET GENE EXPRESSION |
摘要 |
New hybrid or chimeric fusion polypeptide transcription regulators which induce interferon target gene expression are provided for use in anti-viral and anti-proliferative applications. The hybrid fusion proteins comprise the p48 interferon regulatory factor protein, or a functional portion thereof, fused to a transcriptional activation domain (TAD), or a functional portion thereof. More specifically, the p48 interferon regulatory factor protein is fused to a STAT transcriptional activation do main (TAD) (p48-STAT TAD). A particular p48-STAT TAD is p48-S2C, in which S2C is the TAD of STAT2. Another p48- TAD is p48-VP16 TAD, in which p48 is fused to the transcriptional activation domain of the VP16 protein of Herpes Simplex Virus (HSV). The p48- TAD nucleic acid sequences and encoded polypeptides can be employed for anti-viral treatment and for the treatment of cancers, tumors and neoplastic diseases. |
申请公布号 |
WO03031575(A2) |
申请公布日期 |
2003.04.17 |
申请号 |
WO2002US31768 |
申请日期 |
2002.10.03 |
申请人 |
MOUNT SINAIS SCHOOL OF MEDECINE OF NEW YORK UNIVERSITY;HORVATH, CURT, M.;LAU, JOE, F. |
发明人 |
HORVATH, CURT, M.;LAU, JOE, F. |
分类号 |
A61K38/00;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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