NOVEL MACROCYCLIC COMPOUND WITH EXCESS CHIRAL NITROGEN AND METHOD FOR PREPARING THE SAME

摘要

PURPOSE: Provided are a macrocyclic compound with excess chiral nitrogen which can be used for producing a ligand for separation of chiral material or selective asymmetric reaction, and a method for manufacturing a synthetic enzyme. CONSTITUTION: The macrocyclic compound is produced from triamine or tetramine compound obtained by the reaction of aziridine and amine or azide. The triamine(formula 1) or tetramine(formula 2) is reacted with suitable bifunctional, electrophilic compound to synthesize various macrocyclic compounds. The synthesized macrocyclic compounds can be used for producing a ligand for separation of chiral material or selective asymmetric reaction(aldol reaction, epoxy reaction, reduction, and so on), and manufacturing a synthetic enzyme.