Methods and compositions for repair or replacement of joints and soft tissues

摘要

Disclosed herein are methods and implants for enhancing or restoring the mechanical function of collagenous tissue. Specifically exemplified is the replacement or repair of endogenous nucleus pulposus with allogenic, xenogenic, or both nucleus pulposus that has been augmented with growth factors and glycosaminoglycans, via injection into a weakened intervertebral disc. Also disclosed is an implant to restore mechanical function to a damaged vertebral column. Additionally, methods and products for augmenting the extracellular matrix and cell content of a damaged nucleus pulposus through infusion of selected stem cells and other restorative materials are disclosed. The methods and products disclosed may be adapted for use in repair of all soft or hard tissue found in association with articulating joints.