4-HETEROCYCLYLSULFONEAMIDYL-6-METHOXY-5-(2-METHOXYPHENOXY)-2-PYRIDYLPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to 4-heteriocyclylsolfoneamidyl-6-methoxy-5-(2-methoxyphenoxy)-2-pyridylpyrimidine derivatives of the formula (I) where R1 means heterocyclic fragment taken among pyridyl and thiazolyl where this heterocyclic fragment is substituted optionally with (lower) alkyl or (lower) alkenyl and to their pharmaceutically acceptable salts. These compounds are inhibitors of endothelin receptors and therefore they can be used for treatment of patients with diseases associated with anomalous vascular tonus and endothelial dysfunction. EFFECT: valuable medicinal properties of compounds. 9 cl, 3 tbl