PREPARATION OF HIV PROTEASE INHIBITORS

摘要

The present invention is concerned with novel HIV protease Inhibitors of formula (I), as individual isomers, racemates, non-racemic mixtures or mixtures of diastereoisomers; wherein A is a group formulas (II, III), n, R1 , R2, R3 and R4 are as defined in the description or pharmaceutically acceptab le salts thereof. The compounds of formula (I) are peptide mimetics which act a s inhibitors of the HIV aspartyl protease, an essential enzyme in the replicative life cycle of HIV.