PREPARATION OF AN ANHYDROUS QUINOLINE-BASED CETP INHIBITOR BY CRYSTALLIZATION

摘要

This invention relates to methods for preparing anhydrous CETP inhibitor,Formula(I),(2R, 4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester by crystallization (Formula I).