| 发明名称 |
GABA-A RECEPTOR SUBUNITS (.ALPHA.-2,.ALPHA.-3,.ALPHA.-5,.ALPHA.-6,.BETA.-2) AND TRANSFECTED CELLS EXPRESSING THEM |
| 摘要 |
The present invention relates to a stably co-transfected eukaryotic cell lin e capable of expressing a GABA A receptor, particularly a human GABA A receptor, which receptor comprises at least one alpha, one beta and one gamma subunit; to the cloning of novel cDNA sequences encoding the a2, a3, a5, a6 and .beta.2 subunits of the human GABA A receptor; and to the use of the cell line in designing and developing GABA A receptor subtype-selective medicaments.
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| 申请公布号 |
CA2109193(C) |
申请公布日期 |
2003.04.08 |
| 申请号 |
CA19922109193 |
申请日期 |
1992.06.09 |
| 申请人 |
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发明人 |
HADINGHAM, KAREN L.;LE BOURDELLES, BEATRICE;WHITING, PAUL J.;WINGROVE, PETER B. |
| 分类号 |
A61K38/00;C07K14/00;C07K14/705;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12R1/91;G01N33/15;(IPC1-7):C12N15/12;G01N33/566;C12N15/85 |
主分类号 |
A61K38/00 |
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