发明名称 |
PARAMYXOVIRUS VECTOR FOR TRANSFERRING FOREIGN GENE INTO SKELETAL MUSCLE |
摘要 |
It is examined whether or not a recombinant Sendai virus (SeV) vector is usable in transporting a gene into a skeletal muscle by using LacZ reporter gene and insulin-like growth factor gene. As a result, the transgene expression is sustained for 1 month at the longest after the injection. Compared with a control, the transfer of the insulin-like growth factor gene causes a significant increase in regenerated fibers and a significant increa se in slipped muscle fibers, i.e., an indication of enlargement. Also, the tota l muscle fiber number is increased thereby. Thus, it is indicated that the paramyxovirus vector containing Sendai virus achieves the high-level expression of the transgene in the skeletal muscle and that the transfer of the insulin-like growth factor gene with the use of the paramyxovirus vector is seemingly highly useful in treating neuromuscular disorders.
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申请公布号 |
CA2424992(A1) |
申请公布日期 |
2003.04.04 |
申请号 |
CA20012424992 |
申请日期 |
2001.09.26 |
申请人 |
DNAVEC RESEARCH INC. |
发明人 |
MAEDA, MITSUYO;SHIOTANI, AKIHIRO;HASEGAWA, MAMORU;FUKUMURA, MASAYUKI |
分类号 |
A61K38/12;A61K38/30;A61K48/00;A61P21/00;A61P25/02;C07K14/65;C12N15/86;(IPC1-7):C12N15/09;A61K38/00;A61K35/76 |
主分类号 |
A61K38/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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