NOVEL MOLECULES OF THE PYRIN DOMAIN PROTEIN FAMILY AND USES THEREOF

摘要

Diagnostic, screening and therapeutic methods utilizing NBS-1 and PYRIN-1 are disclosed. The methods take advantage of the interactions between NBS-1 or PYRIN-1 and various proteins involved in apoptotic and inflammatory signaling pathways. Also disclosed are methods for identifying modulators of ASC and NF-KκB.