| 发明名称 |
A RECOMBINANT CELL LINE EXPRESSING GPCRx11 AS A FUNCTIONAL RECEPTOR VALIDATED BY ANGIOPEPTIN AND USEFUL FOR SCREENING OF AGONISTS AND ANTAGONISTS |
| 摘要 |
The present invention is related to a G-protein coupled receptor or GPCRx11 similar to rat RTA receptor (37 %) and expressed in testis, thymus and uterus. Aequorin cell line expressing GPCRx11 has been used for screening of tissue extracts and reference ligands. GPCRx11 cells gave a specific signal with synthetic angiopeptin and a somatostatin analog allowing to validate this cell line for screening of natural or synthetic agonists and antagonists. In parallel, extended tissue distribution and polyclonal antibodies have been produced to facilitate GPCRx11 characterisation. |
| 申请公布号 |
EP1297003(A2) |
申请公布日期 |
2003.04.02 |
| 申请号 |
EP20010942923 |
申请日期 |
2001.06.20 |
| 申请人 |
EUROSCREEN S.A. |
发明人 |
LANNOY, VINCENT;BREZILLON, STEPHANE;DETHEUX, MICHEL;PARMENTIER, MARC;GOVAERTS, CEDRIC |
| 分类号 |
A01K67/027;A61K45/00;A61P1/04;A61P1/08;A61P1/14;A61P3/04;A61P3/10;A61P7/10;A61P9/00;A61P9/02;A61P9/04;A61P9/10;A61P9/12;A61P9/14;A61P13/08;A61P17/02;A61P19/08;A61P19/10;A61P25/04;A61P25/06;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P35/04;A61P37/02;A61P37/08;A61P43/00;C07K14/00;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12Q1/02;G01N33/15;G01N33/50 |
主分类号 |
A01K67/027 |
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