发明名称 |
Quinolinyl and benzothiazolyl PPAR-gamma modulators |
摘要 |
<p>Compounds having the formula (I) wherein Ar<1> is substituted or unsubstituted 2-benzothiazolyl or substituted or unsubstituted quinolinyl; X is -O-, -C(O)-, -CH(R<10>)-, -N(R<11>)-, or -S(O)k-; Y is -N(R<12>)-S(O)2-; R<1> is hydrogen or a specified substituent; R<2> is substituted or unsubstituted aryl; and R<3> is halogen or (C1-C8)alkoxy are useful in the treatment or prevention of a condition or disorder mediated by PPAR gamma . In particular, the compounds of the invention modulate the function of PPAR gamma . The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.</p> |
申请公布号 |
SK18352002(A3) |
申请公布日期 |
2003.04.01 |
申请号 |
SK20020001835 |
申请日期 |
2001.06.27 |
申请人 |
TULARIK INC.;JAPAN TOBACCO, INC. |
发明人 |
MCGEE LAWRENCE R.;HOUZE JONATHAN B.;RUBENSTEIN STEVEN M.;HAGIWARA ATSUSHI;FURUKAWA NOBORU;SHINKAI HISASHI |
分类号 |
A61K31/428;A61K31/4439;A61K31/47;A61K31/4725;A61K31/506;A61P3/00;A61P3/04;A61P3/06;A61P3/10;A61P9/10;A61P19/02;A61P29/00;A61P43/00;C07D215/12;C07D215/20;C07D215/36;C07D215/48;C07D277/64;C07D277/68;C07D277/82;C07D417/04;C07D417/12;C07D417/14;(IPC1-7):C07D277/82 |
主分类号 |
A61K31/428 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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