| 摘要 |
A compound of the formula (1) and its salts that may be suitable for treating neoplasia is disclosed, where: R1 is hydrogen, halogen, lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, lower alkylmercapto, lower alkyl sulfonyl, cyano, carboxamide, carboxylic acid, mercapto, sulfonic acid, xanthate or hydroxy; R2 is hydrogen or lower alkyl; R3 hydrogen, halogen, amino, hydroxy, lower alkyl amino, or di-lower alkylamino; R4 is hydrogen, or R3 and R4 together are oxygen; R5 and R6 are hydrogen, lower alkyl, hydroxy-substituted lower alkyl, amino lower alkyl, lower alkylamino-lower alkyl, lower alkyl amino di-lower alkyl, lower alkyl nitrile, -CO2 H, -C(O)NH2, or a C2 to C6 amino acid; R7 is independently selected in each instance from the group consisting of hydrogen, amino lower alkyl, lower alkoxy, lower alkyl, hydroxy, amino, lower alkyl amino, di-lower alkyl amino, amino lower alkyl, halogen, -CO2 H, -SO3 H, - SO2 NH2, or -SO2 (lower alkyl); m and n are integers from 0 to 3; Y is quinolinyl, isoquinolinyl, pyridinyl, pyrinidinyl, pyrazinyl, imidazolyl, indolyl, benzimidazolyl, triazinyl, tetrazolyl, thiophenyl, furanyl, thiazolyl, pyrazolyl, or pyrrolyl, or substituted variants thereof wherein the substituents are halogen, lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxy, -SO2 (lower alkyl) and -SO2 NH2.
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