发明名称 |
METHOD FOR DETECTING CONDITIONS INDICATIVE OF SEPSIS |
摘要 |
The disclosure describes a method for detecting conditions indicative of sepsis. In one embodiment of the invention, an increase in the level of 3-chlorotyrosine or 3-bromotyrosine from the normal level in a sample of body fluid or tissue is indicative of early sepsis or infection. In another embodiment of the invention, the level of 3-chlorotyrosine or 3-bromotyrosine is measured or monitored to determine the response to therapeutic treatment of the infective condition in which a reductuion in the level that existed prior to the treatment is an early sign or indication that the treatment is working in vivo. In a preferred embodiment, the method of the invention is illustrated in a clinically relevant mouse model of sepsis. |
申请公布号 |
WO03025212(A2) |
申请公布日期 |
2003.03.27 |
申请号 |
WO2002US28211 |
申请日期 |
2002.09.05 |
申请人 |
WASHINGTON UNIVERSITY;HEINECKE, JAY, W. |
发明人 |
HEINECKE, JAY, W. |
分类号 |
G01N27/62;C12Q1/02;G01N30/02;G01N30/72;G01N30/88;G01N33/50;G01N33/53;G01N33/68 |
主分类号 |
G01N27/62 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|