发明名称 |
ANTI-PDGF ANTIBODIES AND METHODS FOR PRODUCING ENGINEERED ANTIBODIES |
摘要 |
Methods of making and selecting engineered antibodies and/or antibody fragments provide maximized binding affinity for a predetermined target and minimized immunogenicity when such antibodies are administered to a target species. Libraries containing variants of the engineered antibodies are also provided. In particularly useful embodiments, anti-PGDF antibodies and compositions are produced which are useful in the treatment of various cance rs.
|
申请公布号 |
CA2460587(A1) |
申请公布日期 |
2003.03.27 |
申请号 |
CA20022460587 |
申请日期 |
2002.09.20 |
申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
FREDERICKSON, SHANA;KRETZ-ROMMEL, ANKE;BOWDISH, KATHERINE S. |
分类号 |
C12N15/09;A61K39/395;A61K45/00;A61P35/00;A61P43/00;C07K16/22;C07K16/26;C07K16/46;(IPC1-7):C07K16/00;C07K16/28;C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|