| 发明名称 |
Modulation of PDE11A activity |
| 摘要 |
The invention provides genetically-modified non-human mammals and genetically-modified animal cells containing a functionally disrupted PDE11A gene. Also provided by the invention are methods of screening for agents that modulate PDE11A to modulate spermatogenesis, methods of treating mammals to modulate spermatogenesis, and methods of modulating cAMP and cGMP signal transduction in cells that express PDE11A.
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| 申请公布号 |
US2003061625(A1) |
申请公布日期 |
2003.03.27 |
| 申请号 |
US20010040570 |
申请日期 |
2001.11.01 |
| 申请人 |
BURSLEM MARTYN FRANK;HARROW IAN DENNIS;LANFEAR JEREMY;PHILLIPS STEPHEN CHARLES |
发明人 |
BURSLEM MARTYN FRANK;HARROW IAN DENNIS;LANFEAR JEREMY;PHILLIPS STEPHEN CHARLES |
| 分类号 |
A61K31/4985;A61K31/517;C12N5/02;C12N5/074;C12N9/16;C12N15/85;C12Q1/44;(IPC1-7):A01K67/027;C12N5/06;C12N5/08 |
主分类号 |
A61K31/4985 |
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