发明名称 |
PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS |
摘要 |
A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 .mu.m. More preferably, the proportion of the pore- forming agent is 7-40% (w/w). The composition may further include a bioactiv e agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition c an be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surfac e region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bon e formation and delivering the bioactive agent are provided.
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申请公布号 |
CA2460843(A1) |
申请公布日期 |
2003.03.27 |
申请号 |
CA20022460843 |
申请日期 |
2002.09.20 |
申请人 |
STRYKER CORPORATION |
发明人 |
KULKARNI, SHAILESH C.;TOTH, CAROL ANN;LANDERYOU, TRACY J.;DALAL, PARESH S. |
分类号 |
A61L27/00;A01N43/04;A01N63/00;A61B;A61F2/00;A61F13/00;A61L27/12;A61L27/22;A61L27/56;C07K14/47;C08J9/26;C08J9/28;(IPC1-7):C08J9/26 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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