| 摘要 |
The disclosure describes a method for detecting conditions indicative of sepsis. In one embodiment of the invention, an increase in the level of 3- chlorotyrosine or 3-bromotyrosine from the normal level in a sample of body fluid or tissue is indicative of early sepsis or infection. In another embodiment of the invention, the level of 3-chlorotyrosine or 3-bromotyrosin e is measured or monitored to determine the response to therapeutic treatment of the infective condition in which a reductuion in the level that existed prio r to the treatment is an early sign or indication that the treatment is workin g in vivo. In a preferred embodiment, the method of the invention is illustrat ed in a clinically relevant mouse model of sepsis. |
