| 摘要 |
This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, of the following formula:wherein L and M are selected from the group consisting of carbon and CH, the chemical bond between L and M is selected from the group consisting of a single bond and a double bond,wherein Z4 and Z5 are different and are selected from the group consisting of R14 and where Z4 is R14 when Z5 is and Z4 is when Z5 is R14;wherein A1 is CH;wherein B1 is CH;wherein R17 is selected from the group consisting of aryl, diaryl, triaryl, mono-, di- or tri-substituted aryl, mono-, di- or tri-substituted diaryl, mono-, di- or tri- substituted triaryl, a substituted or unsubstituted heteroaryl and p-aroyl-L-glutamate;wherein R18 is a lower akyl group; andsaid compound capable of inhibiting dihydrofolate reductase and thymidylate synthase. These compounds are useful in the treatment of certain illnesses, including cancer and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in immunocompromised patients.
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