发明名称 |
METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITHIN A CELL |
摘要 |
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. T he methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or a host cell that . In another aspect the invention provides methods for treating patients having suffering from infection, particularly infection with HIV. |
申请公布号 |
CA2457282(A1) |
申请公布日期 |
2003.03.20 |
申请号 |
CA20022457282 |
申请日期 |
2002.09.13 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
BALTIMORE, DAVID;QIN, XIAO-FENG;LOIS-CABALLE, CARLOS |
分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K48/00;A61P31/18;C12N15/113;C12N15/867 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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