发明名称 |
PROCESS FOR PRODUCING CRYSTAL |
摘要 |
<p>The present invention relates to a production method of a crystal of (R)-2-ÄÄÄ3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylÜmethylÜsulfinylÜ benzimidazole . n'H2O (wherein n' is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-ÄÄÄ3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylÜmethylÜsulfinylÜ -benzimidazole . nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.</p> |
申请公布号 |
EP1293507(A1) |
申请公布日期 |
2003.03.19 |
申请号 |
EP20010930131 |
申请日期 |
2001.05.15 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
HASHIMOTO, HIDEO;MARUYAMA, HIDEAKI |
分类号 |
A61K31/4439;A61P1/04;A61P35/00;C07D401/12;(IPC1-7):C07D401/12;A61K31/443 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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