Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease
摘要
<p>The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity for the therapeutic treatment of human cancers in combination with established therapeutic principles. The invention also relates to the use of those compounds for the treatment of tumor metastasis and minimal residual disease. The invention includes the manufacture of a clinically used substance for the treatment of human cancers.</p>
申请公布号
EP1293205(A1)
申请公布日期
2003.03.19
申请号
EP20010121722
申请日期
2001.09.18
申请人
G2M CANCER DRUGS AG
发明人
HEINZEL, THORSTEN, DR.;GOETTLICHER, MARTIN, PD DR.;HENTSCH, BERND, DR.;WELS, WINFRIED STEPHAN, PD DR.;PELICCI, PIER GIUSEPPE, PROF. DR.;MINUCCI, SAVERIO, DR.;HERRLICH, PETER A., PROF. DR.;GRONER, BERND, PROF. DR.