PEPTIDE SEQUENCE THAT FORMS MUCIN SUGAR CHAIN AND TECHNIQUE FOR MODIFYING PROTEIN TO BE LINKED WITH MUCIN SUGAR CHAIN

摘要

An amino acid sequence that can specifically introduce a mucin type sugar chain into a protein or peptide chain and a technique of introducing a mucin type sugar chain into protein or peptide by utilizing such a sequence are disclosed. GalNAc moiety of UDP-GalNAc (where UDP represents uridine 5'-diphosphate and GalNAc represents N-acetylgalactosamine) is introduced into the amino acid X(O) in the presence of UDP-GalNAc: polypeptide .alpha.1, O-GalNAc transferase (O-GalNAc T): X(-1) - X(0 - X(1) - X(2) - X(3) (I) where X(-1) and X(2) represent independently any amino acid, X(0) represents T or S and X(1) and X(3) represent independently any amino acid except that at least one of X(1) and X(3) represents P.