NUCLEAR BODIES

摘要

The compositions and methods described herein are based, at least in part, on fundamental observations concerning nuclear organization and gene expression. More specifically, the studies described below have revealed a new type of nuclear body or intra-nuclear organelle, which is referred to herein as a PAN body (an acronym for PML body adjacent nuclear body). The evidence collected to date supports a role for PAN bodies in nuclear function, gene regulation (or expression), and disease. For example, the studies reveal a structural relationship between PAN bodies and PML bodies, which are implicated in cell proliferation and apoptosis. This relationship and others are discussed further below. Accordingly, the invention features isolated or purified PAN bodies and therapeutic (including prophylactic), diagnostic, and screening methods that utilize PAN bodies.