PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE

摘要

The present invention provides 1,3-dioxolane and 1,3-oxathiolane derivatives that are inhibitors of RNA-dependent RNA viral polymerase. These compounds are also inhibitors of RNA-dependent RNA viral replication and are useful in the treatment of RNA-dependent RNA viral infection. The invention also describes pharmaceutical compositions containing such 1,3-dioxolane and 1,3-oxathiolane derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection. Also disclosed are methods of inhibiting RNA-dependent RNA viral polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the compounds of the present invention.