The invention relates to oral pharmaceutical preparations that comprise a pharmacologically active drug bound to small particles of an ion-exchange resin. Drug-resin complexes are coated with an aqueous based diffusion barrier comprising a water-permeable, film forming polymer that is relatively insoluble in gastrointestinal fluids thereby providing a controllable sustained release of drug under conditions encountered in the gastrointestinal tract. At least some of the barrier coated drug-resin particles may be coated with an enteric coating to provide a tailored release profile.
申请公布号
WO03020242(A1)
申请公布日期
2003.03.13
申请号
WO2002US27401
申请日期
2002.08.29
申请人
SRL TECHNOLOGIES, INC.;MEADOWS, DAVID;YOUNG, PETER;KEYSER, DONALD, J.