USE OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES FOR TREATING CANCER

摘要

Cyclopenta[g]quinazolines of the formula (I): wherein: A is hydrogen or a group OR or NR<0>R<1> wherein R<0> and R<1> are each independently hydrogen C1-4 alkyl, C3-4 alkenyl, C3-4 alkynyl, C2-4 hydroxyalkyl, C2-4 halogenoalkyl or C1-4 cyanoalkyl, or R<0> and R<1> together with the intermediate N form a five- or six-membered heterocylic ring; p is an integer in the range 1 to 4; R<2> is hydrogen, C1-4 alkyl, C3-4 alkenyl, c3-4 alkynyl, C2-4 hydroxyalkyl, C2-4 halogenoalkyl or C1-4 cyanoalkyl; Ar<1> is phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl which may optionally bear one or two subtituents selected from halogeno, hydroxy, amino, nitro, cyano, trifluoromethyl, C1-4 alkyl and C1-4 alkoxy; and R<3> is a group the following formula: (II) and pharmaceutically acceptable salts or esters may be used in the treatment of solid tumours.