ISOLATED DNA SEQUENCES ASSOCIATED WITH MULTIDRUG RESISTANCE IN HUMAN CELLS
摘要
Genomic and cDNA clones of human genes which are selectively amplified or overexpressed in multidrugresistant human tumor cells were isolated. Such clones may be used as probes in diagnostic tests to detect chemotherapy-resistant tumor cells and to predict tumor response to chemotherapy. The complete nucleotide sequence of the coding region of the human mdr1 gene and the complete corresponding amino acid sequence are disclosed.
申请公布号
EP0274482(B2)
申请公布日期
2003.03.12
申请号
EP19870903043
申请日期
1987.03.26
申请人
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人
RONINSON, IGOR, B.;PASTAN, IRA, H.;GOTTESMAN, MICHAEL, M.