PROTEINS HAVING EFFECTS OF CONTROLLING CELL MIGRATION AND CELL DEATH

摘要

It is intended to provide proteins having effects of controlling cell migration and cell death of nerve cells, etc. and DNAs encoding these proteins. In particular, it is intended to provide a method of controlling cell migration and/or cell death and a method of screening a substance capable of promoting or suppressing the effects of controlling cell migration and/or cell death with the use of proteins controlling the mobility and cell death of nerve cells, etc. by interacting an actin-binding protein and thus promoting the decomposition of the actin-binding protein and DNAs encoding these proteins. c-DNAs of S-FILIP, L-FILIP and h-FILIP, each interacting with an actin-binding protein Filamin 1 and thus promoting the decomposition of Filamin 1, thereby negatively controlling cell migration and participating in cell death, are isolated and the full base sequences and amino acid sequences thereof are determined.