发明名称 |
Process for preparing optically active secondary alcohols having nitrogenous or oxygenic functional groups |
摘要 |
A process for preparing optically active secondary alcohols of the general formula (3), [wherein R1 is linear lower alkyl, an aromatic ring group, or the like; A is CH2NR2R3 or the like; n is an integer of 0 to 2; and * represents an asymmetric carbon atom] by asymmetrically hydrogenating a ketone compound of the general formula (1) having nitrogenous or oxygen functional group at any of the a-, beta- and gamma-positions, with selectivity among functional groups by the use of a ruthenium/optically active bidentate phosphine/diamine complex as the catalyst in the presence of hydrogen alone or together with a base. The optically active secondary alcohols obtained by the process are useful as drugs and intermediates for the preparation of drugs.
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申请公布号 |
US2003045727(A1) |
申请公布日期 |
2003.03.06 |
申请号 |
US20020203089 |
申请日期 |
2002.08.06 |
申请人 |
NAKANO SEIJI;NOYORI RYOJI;OHKUMA TAKESHI;ISHII DAI |
发明人 |
NAKANO SEIJI;NOYORI RYOJI;OHKUMA TAKESHI;ISHII DAI |
分类号 |
C07C29/145;C07C41/26;C07C213/00;C07C215/08;C07C215/16;C07C215/30;C07C231/18;C07C233/73;C07C303/40;C07C311/08;C07D209/88;C07D239/42;C07F9/50;(IPC1-7):C07D213/54;C07C215/46;C07D207/04;C07C215/02 |
主分类号 |
C07C29/145 |
代理机构 |
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代理人 |
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主权项 |
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