| 发明名称 |
BIOADHESIVE COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DRUG ABSORPTION |
| 摘要 |
Compositions and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a bioadhesive compound and a second population of carrier particles comprising a penetration enhancer. The bioadhesive extends the residence tim e of the drug and its absorptive potential across the portion of the intestina l mucosa made permeable by the penetration enhancer.
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| 申请公布号 |
CA2458443(A1) |
申请公布日期 |
2003.03.06 |
| 申请号 |
CA20022458443 |
申请日期 |
2002.08.22 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
TILLMAN, LLOYD G.;WEINBACH, SUSAN P.;HARDEE, GREGORY E.;TENG, CHING-LEOU;GEARY, RICHARD S. |
| 分类号 |
C12N15/09;A61K9/06;A61K9/08;A61K9/14;A61K9/16;A61K9/20;A61K9/24;A61K9/28;A61K9/50;A61K31/565;A61K31/7088;A61K38/00;A61K38/43;A61K47/08;A61K47/12;A61K47/14;A61K47/16;A61K47/18;A61K47/22;A61K47/28;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61K48/00;A61P1/00;A61P5/00;A61P5/24;A61P9/00;A61P9/08;A61P9/12;A61P11/10;A61P11/14;A61P19/00;A61P25/02;A61P25/20;A61P25/24;A61P29/00;A61P31/04;A61P35/00;A61P43/00;(IPC1-7):A61K38/00;C07H21/04 |
主分类号 |
C12N15/09 |
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