MOLECULAR INTERACTION SITES OF 23S RIBOSOMAL RNA AND METHODS OF MOLULATING THE SAME

摘要

Polynucleotides comprising molecular interaction sites of 23S rRNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of 23S rRNA by contacting 23S rRNA or prokaryotic cells containing the same with a compund identified by such virtual or actual screening are also provided.