发明名称 |
SYNTHETIC PROCESS FOR THE MANUFACTURE OF AN ECTEINASCIDIN COMPOUND |
摘要 |
Preparation of an ecteinascidin product with a spiroamine-1,4-bridge involves forming a 1,4 bridge using a 1-labile, 10- hydroxy, 18-protected hydroxy, di-6,8-en-5-one fused ring compound. The C-18 protection is removed before spiroamine (preferably spiroquinoline) introduction. An independent claim is included for the manufacture of the ecteinascidin compound involving removing both protecting groups in a single step, according to the scheme. [Image] T : amino protecting group; and T' : hydroxy protecting group. ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given. |
申请公布号 |
EP1287004(A1) |
申请公布日期 |
2003.03.05 |
申请号 |
EP20010929816 |
申请日期 |
2001.05.15 |
申请人 |
PHARMA MAR, S.A. |
发明人 |
CUEVAS, CARMEN;PEREZ, MARTA;FRANCESCH, ANDRES;FERNANDEZ, CAROLINA;CHICHARRO, JOSE LUIS;GALLEGO, PILAR;ZARZUELO, MARIA;MANZANARES, IGNACIO;MARTIN, MARIA JESUS;MUNT, SIMON |
分类号 |
C07D471/18;A61K;A61K31/4995;A61K35/00;A61P31/04;A61P35/00;C07D;C07D221/00;C07D241/00;C07D291/00;C07D317/00;C07D471/22;C07D487/18;C07D491/22;C07D497/22;C07D515/00;C07D515/22 |
主分类号 |
C07D471/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|