Process of preparation of flumethasone 21-acetate, or flumethasone and its 17-carboxyl androsten analogue,申请号US20020162862-传众专利搜索

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发明名称	Process of preparation of flumethasone 21-acetate, or flumethasone and its 17-carboxyl androsten analogue
摘要	A process for the preparation of high purity flumethasone in high yield involves C3 protecting 9,11beta-epoxy-17alpha,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione,21-acetate, fluorinating at 6alpha, removing the C3 protecting group, fluorinating the 9,11-epoxy group. The resulting flumethasone 21-acetate is treated with the methanolic potassium hydroxide in the presence of an oxidation agent, causing a simultaneous hydrolyzation and degradative oxidation, resulting in the formation of 6alpha,9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha-methyl-17beta-carboxy-androsta-1,4-diene-3-one in high yield. Flumethasone 21-acetate is alternatively hydrolyzed to yield flumethasone free alcohol.
申请公布号	US6528666(B1)	申请公布日期	2003.03.04
申请号	US20020162862	申请日期	2002.06.06
申请人	HORIONE LIMITED	发明人	VILLAX IVAN;MENDES ZITA
分类号	C07J3/00;C07J5/00;C07J71/00;C07J75/00;(IPC1-7):C07C50/22;C07D303/06	主分类号	C07J3/00
代理机构		代理人
主权项
地址

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