Process for making a stable organosilanized colloidal silica suspension

摘要

A method of bulk preparation of a stable organosilanized colloidal silica suspension in an aqueous environment, comprises providing an aqueous organosilane solution having a pH in the range of about 2-3 and heated to about 80oC for about 1 hour. A colloidal silica suspension is added to the organosilane solution to form an organosilane-colloidal silica mixture having a final concentration of between about 5% (v/v) and about 10% (v/v) organosilane. The pH of the organosilane-colloidal silica mixture is then adjusted to a pH greater than about 6.0. The suspension is then cured for a period of time effective to produce a stable colloidal suspension, as evidenced by lack of precipitate formation in the presence of physiological salt or acid, wherein said resulting stable colloidal silica suspension is aqueous and non-toxic to cells.