SUSTAINED RELEASE MICROPELLETS AND PROCESS FOR PRODUCING THESAME

摘要

Sustained release micropellets showing a stable sustained-release of a drug without affected by changes in pH value, etc., characterized by being produc ed by coating core grains with a layer containing a water-soluble drug and further forming a film layer containing a water-insoluble polymer compound a nd a plasticizer on the thus obtained grains, having a water-soluble filler lay er located between the water soluble drug-containing layer and the film layer, and having an average grain size of 300 .mu.m or less; medicinal composition s containing these micropellets; and a process for producing the same.