发明名称 USE OF P-AMINOPHENOL DERIVATIVES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
摘要 1. Use of a compound having the formula wherein R1 is hydrogen or -COCH3, and R2 is hydrogen or C1-2 alkyl, or a prodrug thereof for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases. 2. Use according to claim 1, characterized in that the compound having the formula (I) is paracetamol. 3. Use according to claim 1, characterized in that the prodrug of paracetamol is proparacetamol, aminosalol or acetaminosalol or acetaminosalol glycine ester. 4. Use according to claim 1 or 2, characterized in that the disease is Alzheimer's disease. 5. A therapeutic method in which a patient suffering from a neurodegenerative disease is treated with a therapeutically useful quantity of a compound having the formula wherein R1 is hydrogen or -COCH3, and R2 is hydrogen or C1-2 alkyl, or a prodrug thereof. 6. A method according to claim 4, characterized in that the disease is Alzheimer's disease. 7. Use according to claims 4 or 5, characterized in that the compound having the formula (I) is paracetamol. 8. A method according to claim 4, wherein the treatment comprises daily administration of 0.01-200 mg/kg of a compound having the formula (I) or an equivalent quantity of a prodrug of paracetamol. 9. A method according to claims 4 to 6, wherein the treatment comprises daily administration of 10-100 mg/kg of paracetamol or an equivalent quantity of a prodrug thereof. 10. A method according to claim 8, wherein the treatment comprises daily administration of 15-75 mg/kg of paracetamol or an equivalent quantity of a prodrug thereof.
申请公布号 EA003251(B1) 申请公布日期 2003.02.27
申请号 EA19980001028 申请日期 1997.05.15
申请人 ANGELINI RICERCHE S.P.A. SOCIETA' CONSORTILE 发明人 PINZA, MARIO;BRUFANI, MARIO;MILANESE, CLAUDIO
分类号 A61K31/135;A61K31/00;A61K31/165;A61K31/167;A61P25/28;(IPC1-7):A61K31/165 主分类号 A61K31/135
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