发明名称 |
INTERLEUKIN-2 MUTANTS WITH REDUCED TOXICITY |
摘要 |
Interleukin-2 (IL-2) mutants having reduced toxicity, which include full-length IL-2, truncated forms of IL-2 and forms IL-2 that are linked to another molecule are disclosed herein. Particular substitutions within IL-2, particularly within the permeability enhancing peptide region of IL-2 achieve substantial reduction of vasopermeability activity as compared to a wildtype form of the mutant IL-2. Invention IL-2 mutants can be used to stimulate the immune system of an animal and may be used in the treatment of various disorders and conditions. |
申请公布号 |
WO03015697(A2) |
申请公布日期 |
2003.02.27 |
申请号 |
WO2002US25647 |
申请日期 |
2002.08.12 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA;EPSTEIN, ALAN, L.;HU, PEISHENG |
发明人 |
EPSTEIN, ALAN, L.;HU, PEISHENG |
分类号 |
C12N15/09;A61K38/00;A61K38/20;A61K39/39;A61K45/00;A61P31/18;A61P35/00;A61P37/00;A61P37/04;C07K14/55;C07K16/18;C07K19/00;C12N15/12;C12P21/02;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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