A PROCESS FOR THE PREPARATION OF EPOTHILONE ANALOGS
摘要
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
申请公布号
WO02060904(A3)
申请公布日期
2003.02.27
申请号
WO2002US01853
申请日期
2002.01.22
申请人
BRISTOL-MYERS SQUIBB COMPANY;LI, WEN-SEN;THORNTON, JOHN E.;GUO, ZHENRONG;SWAMINATHAN, SHANKAR
发明人
LI, WEN-SEN;THORNTON, JOHN E.;GUO, ZHENRONG;SWAMINATHAN, SHANKAR