THIOL DERIVATIVES AND 1- -METHYL-CARBAPENEM DERIVATIVES HAVING THE SAME AS SUBSTITUENTS

摘要

PURPOSE: Provided are antibiotic 1-β-methyl-carbapenem derivatives of the formula(2) substituted with novel bicyclic thiol derivatives represented by the formula(1) which have stability against DHP-1 enzyme and are effective against resistant bacteria. CONSTITUTION: The method for preparing thiols and carbapenem derivatives comprises the steps of: carrying on the reaction scheme(1) to make thiols and combining them with carbapenem derivatives to make the final product of the formula(2). In the formula(1) and the formula(2), R1 is methyl or ethyl group and R2 is C1-6 alkyl such as methyl, ethyl, propyl, C1-6 cycloalkyl or alkyl substituted with phenyl, vinyl and hydroxyl group.