| 发明名称 |
BIPHENYL DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS |
| 摘要 |
The invention relates to novel biphenyl derivatives of the general formula (I), wherein R4 represents an aromatic heterocycle, and to the physiological ly acceptable salts or solvates thereof. The inventive compounds are integrin inhibitors and are used for combating thromboses, cardiac infarction, corona ry heart diseases, arteriosclerosis, inflammations, tumors, osteoporosis, infections and restenosis following angioplasty or for pathological processe s that are maintained or propagated by angiogenesis.
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| 申请公布号 |
CA2420208(A1) |
申请公布日期 |
2003.02.21 |
| 申请号 |
CA20012420208 |
申请日期 |
2001.08.02 |
| 申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG |
发明人 |
GOODMAN, SIMON;HOLZEMANN, GUNTER;STAHLE, WOLFGANG |
| 分类号 |
A61K31/4168;A61K31/4184;A61P3/10;A61P7/02;A61P9/00;A61P9/10;A61P17/02;A61P19/02;A61P19/10;A61P27/02;A61P29/00;A61P31/00;A61P35/00;A61P41/00;A61P43/00;C07D233/48;C07D233/88;C07D235/30;(IPC1-7):C07D235/30;A61K31/416 |
主分类号 |
A61K31/4168 |
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