DIRECT SELECTION OF PROTEIN COMPLEXES RELEVANT TO THE PHYSIOLOGICAL OR DIAGNOSTIC CONTEXT OF A BIOLOGICAL SPECIMEN

摘要

The invention provides a process for establishing and for direct comparison of liganded protein profiles of biological samples comprising selectively removing potential permeability barriers by disrupting intact membranes present in the samples treating the samples thereafter so as to eliminate unliganded proteins and analyzing the remaining liganded proteins so as to detect any differences between the samples.