| 发明名称 |
HYDROXAMIC ACID DERIVATIVES |
| 摘要 |
A compound of formula (I) wherein : R1 and R2, which may be the same or different, is each a hydrogen atom or a CF3, CF2H or CFH2 group, provided that when one of R<1 >or R<2> is a hydrogen atom the other is a CF3, CF2H or CFH2 group ; and the salts, solvates or hydrates thereof. The compounds are potent MMP inhibitors which advantageously do not cause tendonitis in a relevant animal model. The compounds may be expected to be of use in medicine, especially where the avoidance of side effects such as joint pain is desired.
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| 申请公布号 |
WO03014101(A1) |
申请公布日期 |
2003.02.20 |
| 申请号 |
WO2002GB03656 |
申请日期 |
2002.08.07 |
| 申请人 |
CELLTECH R & D LIMITED;DYKE, HAZEL, JOAN;WATSON, ROBERT, JOHN |
发明人 |
DYKE, HAZEL, JOAN;WATSON, ROBERT, JOHN |
| 分类号 |
A61K31/453;A61P1/00;A61P1/02;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P19/10;A61P25/00;A61P27/02;A61P27/16;A61P29/00;A61P31/00;A61P35/00;A61P37/02;A61P37/08;A61P43/00;C07D405/12;(IPC1-7):C07D309/08;A61K31/445 |
主分类号 |
A61K31/453 |
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