发明名称 |
Drug delivery system exhibiting permeability control |
摘要 |
Microparticles and nanoparticles prepared from oppositely charged polymers are provided in which a drug is incorporated into the core and is conjugated to one polymer by a Schiff-base crosslink. The particles are suitable for use in injectable formulations in which the rate of release of the drug through the particle shell is slowed as compared to noncrosslinked drugs. Enzymatically degradable polymers can be incorporated in otherwise hydrolytically stable particles to provide drug release at particular sites within the body where the enzyme of interest is present.
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申请公布号 |
US2003035838(A1) |
申请公布日期 |
2003.02.20 |
申请号 |
US20020256508 |
申请日期 |
2002.09.27 |
申请人 |
NANODELIVERY, INC. |
发明人 |
PROKOP ALES |
分类号 |
A61K9/00;A61K9/26;A61K9/51;A61K9/70;A61K47/48;(IPC1-7):A61K9/26 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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