发明名称 |
COMBINATION OF A DOPAMINE D2-RECEPTOR AGONIST AND TIOTROPIUM OR A DERIVATIVE THEREOF FOR TREATING OBSTRUCTIVE AIRWAYS |
摘要 |
The present invention relates to a combination of therapeutic agents useful in the treatment of obstructive airways and other inflammatory diseases comprising (I) a dopamine D2-receptor agonist that is therapeutically effective in the treatment of said diseases when administered by inhalation; together with (II) an anti-cholinergic agent consisting of a member selected from the group consisting of tiotropium and derivatives thereof that is therapeutically effective in the treatment of said diseases when administered by inhalation; as well as to a method of treating treating said obstructive airways and other inflammatory diseases comprising administering to said mammal by inhalation a therapeutically effective amount of said combination of therapeutic agents; and a pharmaceutical composition comprising a pharmaceutically acceptable carrier together with said combination of therapeutic agents; and a package containing a pharmaceutical composition for insertion into a device capable of simultaneous or sequential delivery of said pharmaceutical composition in the form of an aerosol or dry powder dispersion to said mammal, where said device is a metered dose inhaler or a dry powder inhaler. It is preferred that said dopamine D2-receptor agonist component be bromocriptine mesylate, naxagolide hydrochloride, cabergoline, pergolide mesylate, quinpirole hydrochloride, or ropinirole hydrochloride; and that said anti-cholinergic agent component be tiotropium bromide. |
申请公布号 |
WO02096422(A3) |
申请公布日期 |
2003.02.20 |
申请号 |
WO2002EP05642 |
申请日期 |
2002.05.23 |
申请人 |
BOEHRINGER INGELHEIM PHARMA KG;YEADON, MICHAEL |
发明人 |
YEADON, MICHAEL |
分类号 |
A61K9/12;A61K9/00;A61K9/14;A61K31/137;A61K31/341;A61K31/351;A61K31/36;A61K31/404;A61K31/417;A61K31/4184;A61K31/454;A61K31/4545;A61K31/46;A61K31/4725;A61K31/4745;A61K31/496;A61K31/498;A61K31/4985;A61K31/517;A61K31/536;A61K31/537;A61K45/06;A61P11/00;A61P11/06;A61P11/08;A61P29/00 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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