Production of homogeneous inhalation powders comprises introducing alternate layers of large excipient particles and small drug particles into a mixing vessel

摘要

Production of inhalation powders comprises introducing equal portions of large excipient particles and equal portions of small drug particles into a mixing vessel in the form of alternate layers, starting with a layer of excipient particles, and then mixing the two components. Production of inhalation powders comprises introducing n+m equal portions of large excipient particles and n equal portions of small drug particles into a mixing vessel in the form of alternate layers, starting with a layer of excipient particles, and then mixing the two components, where n = 1 or more and m = 0 or 1.