METHODS AND COMPOSITIONS FOR CONTROL OF BONE FORMATION VIA MODULATION OF CILIARY NEUROTROPHIC FACTOR ACTIVITY

摘要

The invention relates to the method for treatment, diagnosis and prevention of bone disease and comprises methods including inhibiting or increasing CNTF synthesis, CNTF receptor synthesis, CNTF binding to the CNTF receptor, and CNTF receptor activity. The invention also relates to screening assays to identify compounds that modulate CNTF and/or CNTF receptor activity. The invention further relates to gene therapy methods utilizing CNTF and CNTF-related sequences for the treatment and prevention of bone disease.