| 摘要 |
<p>FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to the improved method of synthesis of compounds of the formula (I) where R4 means H or CH3 involving interaction of compound of the formula (2-C) where R1 means group NO2 with thiosemicarbazide to yield thiosemicarbazone of the formula (TS1) followed by reduction of synthesized compound. Invention proposes also method of synthesis of thiosemicarbazone of the formula (TS2) involving interaction of compound of the formula (2-C) where R1 means group NHP with thiosemicarbazide. Invention proposes also methods of synthesis of intermediate compounds of the formula (2-C) where R1 means NO2,NH2, NHP, NPP, N3 or CO2R2; P and P mean protective groups; R2 means C1-C3-alkyl; R4 means H or CH3/ and compounds of the formula (4) . Proposed methods of synthesis of pyridine-2-carboxaldehyde thiosemi-carbazones allows to increase the yield of end compounds up to 30% from easily available substances. EFFECT: improved methods of synthesis, increased yield. 21 cl, 3 dwg, 1 tbl</p> |
