MODULATION OF ANTIBODY FORMATION IN MAMMALS, APPLICABILITY IN GENE THERAPY AND ANIMAL MODEL GENERATION

摘要

The invention relates to a method of modulating neutralizing antibodies formation against an heterologous protein. The invention also relates to the use of such method to induce a toleration of the immune system towards said protein, such toleration being useful to allow long-term gene therapy or transgene expression. The invention also relates to the use of the method of the invention to provide an animal with a reproducible functional inactivati on phenotype of an endogenous protein of the animal.